Mining cultural treasure in Rome, Assisi, Florence & Siena

How about a room with a view? See spectacular views framed by your hotel room window from Rome, the Vatican, Assisi, Florence, and Siena-San Gimignano. The local guide will take you to the Colosseum, the Duomo, Sistine Chapel, St. Peter's Basilica, St. Francis's Basilica, Accademia, and Siena Cathedral.